Étude sur la corrélation entre faibles niveaux de la mélatonine dans la salive et les symptômes de dépression dans patients psychiatriques.



mélatonine )have been associated with severe depression.">mélatonine )and dimensional measures of depressive symptom severity in young adult psychiatric patients.">L’objectif de cette étude est de fournir des informations sur  la corrélation entre faibles niveaux de la mélatonine dans la salive et les symptômes de dépression dans patients psychiatriques. Les patients avec faibles niveaux de mélatonine peuvent avoir un haut degré de MADRS (un questionnaire diagnostique à 10 éléments utilisé pour évaluer la sévérité de la dépression) que les patients avec d'un niveau plus élevé de mélatonine.mélatonine )have been associated with severe depression.">mélatonine ) and dimensional measures of depressive symptom severity in young adult psychiatric patients.">mélatonine )in the lowest quartile at bedtime had an increased probability of a high MADRS-S score compared to those with the highest levels of melatonin ( mélatonine )(odds ratio 1.39, 95% CI 1.15-1.69, p<0.01).">

Salivary Melatonin in Relation to Depressive Symptom Severity in Young Adults.
PLoS One. 2016;11(4):e0152814
Authors: Sundberg I, Ramklint M, Stridsberg M, Papadopoulos FC, Ekselius L, Cunningham JL

Abstract
Reduced levels of melatonin ( mélatonine )have been associated with severe depression. The aim was to investigate the correlation between salivary melatonin ( mélatonine )and dimensional measures of depressive symptom severity in young adult psychiatric patients. Levels of melatonin ( mélatonine )were analyzed in six saliva samples during waking hours from 119 young adult patients under outpatient psychiatric care. Melatonin levels were tested for association with the severity of depressive symptoms using the self-rating version of the Montgomery Åsberg Depression Rating Scale (MADRS-S). Where possible, depressive symptoms were assessed again after 6±2 months of treatment. Response was defined as decrease in MADRS-S by ≥50% between baseline and follow-up. Patients with levels of melatonin ( mélatonine )in the lowest quartile at bedtime had an increased probability of a high MADRS-S score compared to those with the highest levels of melatonin ( mélatonine )(odds ratio 1.39, 95% CI 1.15-1.69, p<0.01). A post hoc regression analysis found that bedtime melatonin ( mélatonine )levels predicted response (odds ratio 4.4, 95% CI 1.06-18.43, p<0.05). A negative relationship between salivary melatonin ( mélatonine )and dimensional measures of depressive symptom severity was found in young patients under outpatient psychiatric care. Bedtime salivary melatonin ( mélatonine )levels may have prognostic implications.

PMID: 27042858 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/27042858?dopt=Abstract


Melatonine - Multilenguages section Key Melatonin