Le rôle de la mélatonine dans la prévention de la Stéatose hépatique et peut améliorer les resultats après la greffe de foie.



Dans cet article de l’université de Zaragoza avec  la coopération University of Texas Health Science Center at San Antonio a été mise en évidence la efficacité de la melatonine dans la prévention de la Stéatose hépatique et l’amélioration de les resultats après la greffe de foie. La stéatose est caractérisée par la présence de graisse dans les hépatocytes et entraîne des perturbations sévères.

Melatonin role preventing steatohepatitis and improving liver transplantation results.
Cell Mol Life Sci. 2016 Mar 29;
Authors: Esteban-Zubero E, García-Gil FA, López-Pingarrón L, Alatorre-Jiménez MA, Ramírez JM, Tan DX, García JJ, Reiter RJ

Abstract
Liver steatosis is a prevalent process that is induced due to alcoholic or non-alcoholic intake. During the course of these diseases, the generation of reactive oxygen species, followed by molecular damage to lipids, protein and DMA occurs generating organ cell death. Transplantation is the last-resort treatment for the end stage of both acute and chronic hepatic diseases, but its success depends on ability to control ischemia-reperfusion injury, preservation fluids used, and graft quality. Melatonin is a powerful endogenous antioxidant produced by the pineal gland and a variety of other because of its efficacy in organs; melatonin ( mélatonine )has been investigated to improve the outcome of organ transplantation by reducing ischemia-reperfusion injury and due to its synergic effect with organ preservation fluids. Moreover, this indolamine also prevent liver steatosis. That is important because this disease may evolve leading to an organ transplantation. This review summarizes the observations related to melatonin ( mélatonine )beneficial actions in organ transplantation and ischemic-reperfusion models.

PMID: 27022943 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/27022943?dopt=Abstract


Melatonine - Multilenguages section Key Melatonin