Étude pilote pour le traitement de maux de tê...">

Réduire la fréquence de maux de tête avec la mélatonine



Étude pilote pour le traitement de maux de tête avec la mélatonine. L’objet de cette étude réalisé par l’université d’ Athènes était de évaluer  l’efficacité potentiel de la mélatonin  pour la prévention de maux de tête. Les résultats obtenus après adjonction de 4 mg 30  minutes avant se coucher au cours des 6 mois  sont importants: la mélatonine a aidé à réduire la fréquence de maux de tête dans les patients.

Melatonin 4 mg as prophylactic therapy for primary headaches: a pilot study.

Funct Neurol. 2016 Jan-Mar;31(1):33-7
Authors: Bougea A, Spantideas N, Lyras V, Avramidis T, Thomaidis T

Abstract
There is growing evidence that headaches are connected to melatonin ( mélatonine )secretion. Our aim was to assess the potential effectiveness of melatonin ( mélatonine )for primary headache prevention. Forty-nine patients (37 with migraine and 12 with chronic tension-type headache, TTH) were prescribed oral melatonin, 4 mg, 30 minutes before bedtime for six months. Forty-one (83.6%) of the 49 patients completed the study, while eight dropped out for personal reasons. A statistically significant reduction in headache frequency was found between baseline and final follow-up after six months of treatment (p=0.033 for TTH patients and p<0.001 for migraineurs). The Headache Impact Test score was significantly reduced in both groups of headache patients (p=0.002 and p<0.001, respectively). At baseline, melatonin ( mélatonine )levels, measured both during a headache attack and a pain-free period, did not differ between patients with TTH and migraineurs (p=0.539 and p=0.693, respectively), and no statistically significant differences in Hamilton Depression Rating Scale scores were found between the two groups. Melatonin 4 mg as prophylactic therapy for primary headaches: a pilot study This pilot study shows promising results, in terms of headache frequency reduction and daily quality of life improvement, in both groups.

PMID: 27027892 [PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/27027892?dopt=Abstract

Melatonine - Multilenguages section Key Melatonin